Excellent question! We need to define danger. Number of people killed, amount of human misery caused, risk to populations? The biggest diseases in history were probably things like the black death and 1918 spanish flu. The government’s COBRA guidelines put an emergent unknown influenza as the highest risk today. I’d probably go with that…
The most dangerous diseases are probably the ones we can’t cure yet 😉 If we don’t have a cure and we know it can kill you, then it is dangerous – doesn’t matter if it’s a new strain of flu or a deadly genetic disease! Of course, if it’s something that can spread, it’s more of a worry. But once we invent a cure, it stops being dangerous!
In terms of the most dangerous disease for one person to catch, there are lots which are still always fatal. I think the one I’d least like is anthrax – it’s infectious, so you need to be isolated, it’s almost always fatal, and it has a whole host of terrible symptoms. Luckily, it’s extremely rare.
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